It is usually caused by narrowing of your coronary arteries due to a build-up of a fatty substance called atheroma. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. It works and leaves the body quickly, so it needs to be taken twice a day. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. It can cause your blood pressure to become dangerously low. Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. Do not use medications containing isosorbide dinitrate while using isosorbide mononitrate. isosorbide mononitrate, along with Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. What side effects can this medication cause? Thirty percent of the patients never experienced headache from the given dosages. But only about 25% of people who take herbal supplements tell their health care providers. Advertising revenue supports our not-for-profit mission. Do not take a double dose to make up for a missed one. Ginkgo. Alcohol can make the side effects from isosorbide worse. Clipboard, Search History, and several other advanced features are temporarily unavailable. Do not take more or less of it or take it more often than prescribed by your doctor. Unauthorized use of these marks is strictly prohibited. Herbal supplements can strongly affect the body. To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. Patient is a UK registered trade mark. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. An official website of the United States government. Tell your doctor if this medication stops working well (for example, you have more frequent or worsening chest pain). Available for Android and iOS devices. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time. If you notice other effects not listed above, contact your doctor or pharmacist. Diabetes treatment: Can cinnamon lower blood sugar? Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as isosorbide dinitrate, nitroglycerin); or if you have any other allergies. Isosorbide comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. Herbal supplements and heart medicines may not mix, Your blood pressure, if you also take a drug to treat high blood pressure, Beta blockers, such as atenolol (Tenormin), nadolol (Corgard) or propranolol (Inderal LA, Innopran XL), Calcium channel blockers, such as diltiazem, nifedipine (Procardia) and verapamil (Calan SR, Verelan), Nitrates, such as nitroglycerin (Nitrostat, Nitro-Dur, others) and isosorbide (Isordil, Bidil), Statins, such as atorvastatin (Lipitor), lovastatin (Altoprev) and rosuvastatin (Crestor), Anti-rejection medicine, also called immunosuppressant medicine, such as cyclosporine (Gengraf, Neoral, Sandimmune). What is the difference between the immediate-release (IR) and extended-release (ER) versions of isosorbide mononitrate (Monoket)? Manufacturer's PIL, Isosorbide mononitrate 10 mg tablets; Merus Labs Luxco S.a.R.L, The electronic Medicines Compendium. The authors assessed the occurrence of angina pectoris and headache by diary cards while taking into account the number of isosorbide dinitrate sublingual puffs and paracetamole tablets required. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. health information, we will treat all of that information as protected health The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. I would rather take the chance of a heart attack than have no quality of life. My EKG showed Assess your symptoms online with our free symptom checker. This content does not have an Arabic version. You need to take it every day in order for it to work. It is used to treat and prevent a wide range of different conditions. This is a condition where the heart does not beat as efficiently as it should. Read our editorial policy. Learn to reduce stress through mindful living. Try our Symptom Checker Got any other symptoms? Dated October 2016. Isosorbide mononitrate (Monoket) can cause your blood pressure to drop somewhat. Natural remedies for depression: Are they effective? Accessed Sept. 7, 2022. Valerian: A safe and effective herbal sleep aid? URL of this page: https://medlineplus.gov/druginfo/meds/a682348.html. Egton Medical Information Systems Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. 2006 Apr;95(4):217-23. doi: 10.1007/s00392-006-0367-x. Accessed Sept. 7, 2022. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Isosorbide dinitrate (Isordil) is available as both a short-acting tablet and long-acting capsule. Does Viagra add to the risks of melanoma? See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. Store in a cool, dry place, away from direct heat and light. Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen, aspirin). tell your doctor if you may be dehydrated, if you have recently had a heart attack, or if you have or have ever had heart failure, low blood pressure, or hypertrophic cardiomyopathy (thickening of the heart muscles). Take the container with you, even if it is empty. Natural Medicines. Accessed Sept. 7, 2022. ask your doctor about the safe use of alcoholic beverages while you are taking isosorbide. All rights reserved. The information on this page is written and peer reviewed by qualified clinicians. Isosorbide mononitrate. The list below does not include all possible drug interactions with isosorbide mononitrate (Monoket). This activity describes the indications, action, and contraindications for isosorbide as a valuable agent in treating angina pectoris due to coronary artery disease, heart failure with reduced . If you have recently had a head injury or a heart attack. Prescription and OTC When used regularly on a long-term basis, this helps prevent angina attacks from occurring. Saper RB. May also be prescribed off label for Esophageal Spasm. from the best health experts in the business. Isosorbide mononitrate (Monoket) is good for a specific type of chest pain (called angina), but it can cause headaches or dizziness after you take it. Follow directions about how much medicine to take. AskMayoExpert. To view a report comparing 3 (or more) medications, please sign in or create an account. Review/update the If you forget to take a dose, take it as soon as you remember. Use this medication regularly to get the most benefit from it. You may report side effects to the FDA at 1-800-FDA-1088. Isosorbide mononitrate (Monoket) is not known to affect the kidneys. It is not intended as medical advice for individual conditions or treatment. See also: aspirin side effects in more detail. For haemoglobin formation vit. This branded product is no longer on the market. Can isosorbide mononitrate cause problems? This is not a complete list of possible side effects. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Take them to your local pharmacy which will dispose of them for you. PMC Your provider might temporarily have you stop isosorbide mononitrate (Monoket) if this happens. Each day, take the first dose when you wake up, then take the second dose 7 hours later. Headaches can be a sign that the medicine is working, and they might lessen with continued use of the medication. Make sure laboratory personnel and all your doctors know you use this drug. Isosorbide mononitrate is used to prevent chest pain (angina) in patients with a certain heart condition (coronary artery disease). Medicines containing Isosorbide Mononitrate. Headache is often a sign that this medication is working. [2] See also: nitroglycerin side effects in more detail. If you have any questions about this medicine ask your pharmacist. GoodRx works to make its website accessible to all, including those with disabilities. Treatment and prognosis of heart failure with preserved ejection . Moderately clinically significant. For details see our conditions. If headaches continue or become severe, tell your doctor promptly. Call your doctor for medical advice about side effects. Isosorbide mononitrate is used to prevent chest pain ( angina) in patients with a certain heart condition ( coronary artery disease ). Bookshelf Copyright 2023 IBM Watson Health. amlodipine, lisinopril, aspirin, metoprolol, furosemide, carvedilol, propranolol, spironolactone, atenolol, diltiazem. 1996 Dec;3(12):802-806. doi: 10.1097/00045391-199612000-00003. Accessibility This site needs JavaScript to work properly. Does Isosorbide Mononitrate interact with other medications? Do not change the dosing times unless directed by your doctor. What special precautions should I follow? Accessed Sept. 7, 2022. Erectile dysfunction medications (e.g., sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis)) cannot be taken while you're taking isosorbide mononitrate (Monoket). There are no data on passage of isosorbide mononitrate in human milk, but some excretion seems likely. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Coenzyme Q-10 Natural Medicines. Am J Ther. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Canada residents can call a provincial poison control center. the unsubscribe link in the e-mail. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. It is important that you follow the instructions your doctor gives to you about when to take your doses. Bauer B (expert opinion). Prescription and OTC Aspirin relieves pain and inflammation and helps to thin the blood. Profen and Metoclopramide drug interaction, Metoclopramide and Nitrostat drug interaction, Metoclopramide and Alfentanil drug interaction, Risperdal and Metoclopramide drug interaction. Before Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Although unlikely, when this medication is used for a long time, it may not work as well and may require different dosing. Yet many herbal supplements may interact with heart disease medicines. Contraindications: Isosorbide mononitrate should not be used in cases of acute myocardial infarction with low filling pressure, acute circulatory failure (shock, vascular collapse), or hypertrophic obstructive cardiomyopathy (HOCM), constrictive pericarditis, low cardiac filling pressures, aortic/mitral valve stenosis and diseases associated with a raised intra-cranial pressure e.g following a head trauma and including cerebral haemorrhage. Sildenafil ( Viagra ), tadalafil ( Cialis ), avanafil ( Stendra ),and vardenafil ( Levitra) increase the blood pressure lowering effects of isosorbide mononitrate and may cause excessive reductions in blood pressure. In Canada - Call your doctor for medical advice about side effects. If your chest pain attacks happen more often, last longer, or become more severe at any time during your treatment, call your doctor. Evening primrose. Federal government websites often end in .gov or .mil. If you have an underactive thyroid gland. Isosorbide dinitrate dose 30-120 mg daily in divided doses. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. I took this for 4 days, and my headaches were unbearable. Do not drink alcohol while taking View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur:Less commonAbnormal heart soundabsence of or decrease in body movementarm, back, or jaw painblack, tarry stoolsbladder painbleeding after defecationbleeding gumsblood in the urine or stoolsblurred visionbody aches or painburning while urinatingburning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelingschest pain or discomfortchest tightness or heavinesschillscold sweatscoldsconfusionconvulsionscough or hoarsenessdecreased urinediarrheadifficult or labored breathingdifficult, burning, or painful urinationdilated neck veinsdizzinessdizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting positiondry mouthear congestionextra heartbeatsfaintingfast, slow, irregular, pounding, or racing heartbeat or pulsefever or chillsflu-like symptomsfrequent urge to urinatefrequent urinationgeneral feeling of discomfort or illnessheadacheheadache, severe and throbbingheart murmurincreased need to urinateincreased sweatingincreased thirstincreased volume of pale, dilute urineirregular breathingitching, pain, redness, or swelling on the legjoint pain, stiffness, or swellinglightheadednessloss of appetiteloss of voicelower back, side, or stomach painmuscle aches and painsmuscle crampsnasal congestionnausea or vomitingnervousnessnumbness or tingling in the hands, feet, or lipspain or discomfort in the arms, jaw, back, or neckpain, tension, and weakness upon walking that subsides during periods of restpartial or slight paralysispassing urine more oftenpinpoint red or purple spots on the skinpounding in the earsrunny noseshakiness in the legs, arms, hands, or feetshiveringsneezingsore on the legsore throatsudden decrease in the amount of urinesweatingswellingswelling of the face, fingers, feet, or lower legstightness in the chesttrembling or shaking of the hands or feettrouble sleepingtroubled breathinguncomfortable swelling around the anusunusual bleeding or bruisingunusual tiredness or weaknessvomiting of blood or material that looks like coffee groundsweaknessweight gainRareBluish-colored lips, fingernails, or palmsdark urinepale skinrapid heart rateGet emergency help immediately if any of the following symptoms of overdose occur:Symptoms of overdoseBlurred or loss of visionbulging soft spot on the head of an infantchange in consciousnesschange in the ability to see colors, especially blue or yellowcold, clammy skindisturbed color perceptiondouble visionfeeling of constant movement of self or surroundingshalos around lightsheadache, severe and throbbingloss of consciousnessnight blindnessoverbright appearance of lightsparalysissensation of spinningtunnel visionSome side effects may occur that usually do not need medical attention. HHS Vulnerability Disclosure, Help This is called a medicine interaction. Usually avoid combinations; use it only under special circumstances. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. View World Anti-Doping Agency classifications, Prevention of Thromboembolism in Atrial Fibrillation, Prosthetic Heart Valves - Thrombosis Prophylaxis, Prosthetic Heart Valves - Mechanical Valves - Thrombosis Prophylaxis, Revascularization Procedures - Prophylaxis. It works to relax your blood vessels. Let your provider know if you are using any medications for erectile dysfunction before you start taking isosorbide mononitrate (Monoket). This risk may be even higher for certain groups. The short-acting tablet is usually taken as 10 mg to 40 mg by mouth 2 or 3 times daily with at least a 14 hour period of time per day where you don't take any doses. Hawthorn. If it is within 2 hours of the next dose, skip the missed dose. Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). There are 7 disease interactions with isosorbide mononitrate which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Check with your doctor immediately if any of the following side effects occur: burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, slow, irregular, pounding, or racing heartbeat or pulse, itching, pain, redness, or swelling on the leg, numbness or tingling in the hands, feet, or lips, pain or discomfort in the arms, jaw, back, or neck, pain, tension, and weakness upon walking that subsides during periods of rest, shakiness in the legs, arms, hands, or feet, swelling of the face, fingers, feet, or lower legs, trembling or shaking of the hands or feet, vomiting of blood or material that looks like coffee grounds, Bluish-colored lips, fingernails, or palms. Some of these medicine interactions can be risky. Many common herbal supplements interact with common heart medicines. Isosorbide mononitrate is a nitrate-class drug used for the prophylactic treatment of angina pectoris; that is, it is taken in order to prevent or at least reduce the occurrence of angina. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). Which drugs or supplements interact with isosorbide mononitrate? https://naturalmedicines.therapeuticresearch.com. Daily headaches are a common side effect. To use the sharing features on this page, please enable JavaScript. You can start a phase IV clinical trial to monitor Isosorbide mononitrate safety and effectiveness. Data were assessed for carryover and time effects. See the full pregnancy warnings document. View more, Nitroglycerin dilates veins, relieving chest pain and lowering blood pressure. Of the total drug interactions, View interaction reports for isosorbide mononitrate and the medicines listed below. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. In the US - Call your doctor for medical advice about side effects. Unable to load your collection due to an error, Unable to load your delegates due to an error. You may opt-out of email communications at any time by clicking on If you have been told by a doctor you have low levels of iron in your blood (anaemia), or low levels of oxygen in your blood (hypoxaemia). If you have ever had an allergic reaction to a medicine. Then, there was a two-week placebo washout, after which the alternative treatment was given. This content does not have an English version. Liperoti R, et al. Duplication for commercial use must be authorized by ASHP. Licorice. Classes: Nitrates, Angina Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths tablet 10mg 20mg. Is isosorbide mononitrate (Monoket) the same as nitroglycerin (Nitrostat)? We study millions of patients and 5,000 more each day. Many people using this medication do not have serious side effects. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 2017; doi:10.1016/j.jacc.2016.11.078. Side effects : headache, mild dizziness Higher than recommend dosage of sublingual isosorbide dinitrate for treating angina pectoris: a case report and review of the literature. It works by relaxing the blood vessels so the heart does not need to work as hard and therefore does not need as much oxygen. Isosorbide mononitrate helps to prevent angina chest pain from developing. Nitrates (eg, isosorbide dinitrate, isosorbide mononitrate, nitroglycerin). What are the interactions of Isosorbide Mononitrate ? This medication performs a vasodilatory function and is therefore used as a treatment for high blood pressure. Upgrade to Patient Pro Medical Professional? Your body can get used to isosorbide mononitrate (Monoket), and the same amount of medication might no longer work as well as it used to. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Conclusions: Mayo Clinic does not endorse companies or products. Consult your doctor for more details. It also relaxes and widens blood vessels in your heart (coronary arteries) which increases the flow of blood to your heart muscle. (3) The overall number of headache attacks in the first period of active treatment was significantly higher than in the second period irrespective of the dosages given. This site complies with the HONcode standard for trustworthy health information: verify here. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. You can take your doses either before or after meals. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Cardizem may also be used for purposes not listed in this medication guide. Modified-release nitrate preparations: use a once-daily dose to maintain a nitrate-low period and thus minimize tolerance. The tablet usually is taken two or three times daily. Cao HY, Wu HD, Song ZK, Tang ML, Yang S, Liu Y, Qin L. Pan Afr Med J. Integrative medicine (complementary and alternative medicine). Talk to your doctor if you are using marijuana (cannabis). Should I avoid certain foods while taking Isosorbide Mononitrate? Is not subject to the Controlled Substances Act. If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or ada@goodrx.com so that we can provide you with the services you require through alternative means. Use of herbal products and potential interactions in patients with cardiovascular diseases. 7.6 out of 10 from a total of Unless your doctor tells you otherwise, continue your normal diet. St. Joseph 81 mg Aspirin Enteric Safety-Coated. Erectile dysfunction medications (e.g., sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis)) cannot be taken while you're taking isosorbide mononitrate (Monoket). It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as glyceryl trinitrate (GTN), for if you get angina pain. Keep all medicines out of the reach and sight of children. Available for Android and iOS devices. Selected from data included with permission and copyrighted by First Databank, Inc. What happens if I stop taking isosorbide mononitrate (Monoket)? Isosorbide mononitrate should not be used in patients with severe anaemia, severe hypotension, closed angle glaucoma or severe hypovolaemia.Isosorbide mononitrate may give rise to postural hypotension and syncope in some patients. The information eHealthMe analyzes includes: Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. This chest pain can feel more intense or painful than it was before you began taking isosorbide mononitrate (Monoket). Does Isosorbide Mononitrate interact with other drugs you are taking? 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Do not store in the bathroom. Avoid combinations; the risk of the interaction outweighs the benefit. Never give it to other people even if their condition appears to be the same as yours. If you are taking other medicines, including those available to buy without a prescription, as well as herbal or complementary medicines. Isosorbide (C6H10O4), also called D-Isosorbide dinitrate, is a bio-product sourced from starch. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). This does not necessarily mean no interactions exist. A randomized, double-blind, cross-over study. If you buy any medicines, please check with a pharmacist that they are suitable for you to take with isosorbide mononitrate. You may report side effects to the FDA at 1-800-FDA-1088. Natural Medicines. Accessed Sept. 7, 2022. About one-half of adults in the United States say they have used one or more supplements in the past 30 days. We comply with the HONcode standard for trustworthy health information. information submitted for this request. Please enable it to take advantage of the complete set of features! Registered number: 10004395 Registered office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19 6BA. It is in the nitrate class of drugs. https://naturalmedicines.therapeuticresearch.com. Unless there is a specific reason you need the brand, the generic medication will be a better value. Accessed Sept. 7, 2022. Cleophas TJ, Niemeyer MG, van Der Wall EE. Normal ecg doesn't rule out heart disease. In: Current Medical Diagnosis & Treatment 2022. B12 and folic acid is essential along with iron. Nitrates in the management of acute coronary syndrome. Aspirin relieves pain and inflammation and helps to thin the blood. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Alternative cancer treatments: 11 options to consider. It works more slowly and lasts for about 12 hours, so you only need to take it once a day. B complex. Isosorbide mononitrate Aspirin Prescription only Prescribed for Angina Pectoris Prophylaxis, Heart Failure. It might help to keep the room cool and use a fan. Do infrared saunas have any health benefits? If you are having an operation or dental treatment, please remember to tell the person carrying out the treatment which medicines you are taking. For these reasons, before you start taking isosorbide mononitrate it is important that your doctor knows: Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Your doctor may tell you to take a pain reliever to treat your headaches. WebMD does not provide medical advice, diagnosis or treatment. government site. This medicine is available only with your doctor's . Consult your doctor before breast-feeding. For instance, many herbal supplements that are used often interact with the blood thinner warfarin (Jantoven). Take this medication by mouth as directed by your doctor, usually twice a day. 19 are major, 174 are moderate, and 2 are minor. Longer-acting tablets and capsules are taken once daily in the morning.
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