PDF Safety Data Sheet - Parchem PharmaCentral 2021 . Thus, Avicel contributes no or very few calories to the food system. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. Heavy metals, % NMT 0.001 PDF Safety Data Sheet - Fmc To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. [FMC Study Number I92-1464]. Packaging: 34 x 50 kgs fiber drums. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. q86@on$^X_HuH;3` <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> EMCOCEL - JRS Pharma Microcrystalline Cellulose; Cellulose; Functions. Microcrystalline Cellulose MSDS - Newseed Chemical Co., Limited gac74 [#B6`Wnw7 The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. ( Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. /Parent 3 0 R 102331. Hi, let us know if you have any questions as you visit our website. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. 1 0 obj The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Browse Avicel PH-101 and related products at MilliporeSigma. Alginates also function as actives in some anti-reflux products. Validity Area. Material safety data sheet - FMC Corporation. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. <> Microcrystalline Cellulose / Avicel PH-102. There is a secret ingredient in your burgers: wood pulp - Quartz Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. ES454445A1 - Procedimiento para preparar una crema lactica de buena con They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. 4. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe Product Name: Microcrystalline Cellulose 1.2. endobj %PDF-1.4 United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. The table below shows the most common physicochemical parameters of this raw material. /Contents 4 0 R Gloves, eye protection and a dust mask should be used. /Resources 2 0 R Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. Product and Company Identification . PDF MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Battista, O. Microcrystalline Cellulose Excipient | Uses, Suppliers, and ETHOCEL premium ethylcellulose resins are water-insoluble polymers. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. <> Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. *r_ *?~4$ &0Y# . The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. Some substance identifiers may have been claimed confidential, or may . 2021 Annual Report. Microcrystalline cellulose (cas 9004-34-6) SDS(Safety Data Sheet) /MSDS << Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. endobj Created Date: 2/10/2020 8:51:41 PM . Doses up to 30 g per day appear to be . CAS 9004-34-6, pH 5 - 7.5. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. We can send by Fedex, by ship or by plane according to international rules. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. <> It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. Micro Crystalline Cellulose - Accent Microcell Pvt. Ltd. Instead, they obtained a stable colloidal suspension. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Earth Supplied Products LLC. FMC Corporation. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Learn about FMC's differentiated biologically-based crop solutions. };khd5x=fr << 0.25 - 0.37. X\o^ Cellulose microcrystalline MSDS - 102331 - Merck Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Avicel Microcrystalline Cellulose Physical Properties. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. Test Data Available. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. If breathing is difficult or if . They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Go to Investor Relations. Avicel RC 591 MSDS CasNo.51395-75-6 - lookchem.com Product Name: Microcrystalline Cellulose E460 1.2. endobj It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. No. l~5C 4 0 obj An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. ( 4 0 obj Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. EINECS #: 232-674-9 1.7. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Molecular weight: Not Applicable 1.5. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. Delivering efficient and robust formulations. A family of polysaccharide products that allow distinctive drug delivery solutions. EMCOCEL XLM 90. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Document(s): certificate data msds. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. . No. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. endstream In 1964 FMC, Corporation . IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. 5 0 obj Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. : 9004-34-6 Date Approved: 01/31/2008 . >> Aqueous suspensions of microcrystalline cellulose have . pH 6.0 to 8.0 . 2 0 obj Avicel PC 611 Microcrystalline Cellulose. (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC Avicel RC-591 & CL-611 | IMCD US {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. PDF (2.77 mb) 2021 FMC Sustainability Report. stream Find answers in our support articles. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Biologicals by FMC. We know that our customers need to provide reliable and consistent products to their patients. It is . Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. PDF Safety Data Sheet However, if handling bulk powders, observance of appropriate safeguards is recommended. Home. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. Avicel Microcrystalline Cellulose: Chemical Identifiers. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . undefined. stream Superior Performance: Provides excellent water uptake and rapid swelling . Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Synonyms: Cellulose, Cellulose powder, Cotton linters. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. It is available in different grades and particle sizes. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. % cas:9000-11-7 msds Carboxymethyl cellulose. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. INCI. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * Safety Data Sheet (SDS) Viewer. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. B;vLZpHU%ChUyD+[ Chemical Formula: (C6H10O5)n 1.4. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Manufacturer: FMC BioPolymer. cas:9032-51-3 msds CELLULOSE PAB. . Global Microcrystalline Cellulose Market (MCC) Size Will Reach US$ 1360 . Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Catalog Number 102331. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. Global Wood Pulp Based Microcrystalline Cellulose Market - Industry Reports GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. Revision No. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. Microcrystalline Cellulose - an overview | ScienceDirect Topics AVICEL RC 581 at Rs 140/kg | Pharmaceutical Excipients in - IndiaMART Your file is uploaded and ready to be published. Microcrystalline Cellulose. Microcrystalline Cellulose as Pharmaceutical Excipient It is, however, a good source of fibre. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM 1. Avicel PH-101 - Cellulose, Cellulose powder PDF PRODUCT OVERVIEW: Avicel PH-200 - Signet The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. There may be more fiber in your food than you realized. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? endobj Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. . !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? >> Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. . Material safety data sheet - FMC Corporation - YUMPU It flows and compresses extremely well, properties that endear this material wide scope of use in many fields.
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